| List of Abbreviations | 第1-8页 |
| PartⅠ Isolation and identification of breast cancer stem-like cells | 第8-51页 |
| Abstract | 第9-14页 |
| 摘要 | 第14-18页 |
| 1 Introduction | 第18-20页 |
| 2 Method and Materials | 第20-24页 |
| ·Isolation and in vitro expansion of progenitor cells from breast tumor specimens | 第20页 |
| ·Flow-cytometric analysis of breast carcinoma-derived cancer stem-like cells | 第20-21页 |
| ·In vivo tumorigenesis analysis by injecting mammospheric cells into animals | 第21页 |
| ·Priming of human DCs with breast cancer stem-like cells lysates | 第21-22页 |
| ·T-cell stimulation and cytotoxic T-cell assays against BSCs | 第22页 |
| ·IFN-y ELISPOT assay cytotoxic T-cell assays against BSCs | 第22-23页 |
| ·DC-stimulating cytotoxic T cells vaccination in a breast cancer mice model | 第23页 |
| ·Survival and Statistical Analysis | 第23-24页 |
| 3 Results | 第24-42页 |
| ·Mammosphere growth of breast carcinoma-Derived Breast Cancer Stem-Like Cells and its expression of stem cells markers | 第24-29页 |
| ·Comparison of stem cells markers between the mammospheric cells and the adherent cells | 第29-33页 |
| ·Evaluation of tumorigenesis by in situ transplantation of breast cancer cells in vivo | 第33-35页 |
| ·Vaccination with Dendritic Cells Loaded with Breast Cancer Stem-Like Cell Elicits Specific cytotoxic T lymphocytes in vitro | 第35-38页 |
| ·IFN-γ ELISPOT assay of Specific cytotoxic T lymphocytes Elicited Dendritic Cells Loaded with Breast Cancer Stem-Like Cells | 第38-40页 |
| ·DC Vaccination Using Breast Cancer Stem-Like Cell Prolongs Survival in a BSC Breast Tumor Model | 第40-42页 |
| 4 Discussion | 第42-45页 |
| 5 Conclusion | 第45-46页 |
| References | 第46-51页 |
| Part Ⅱ CYP2C93 variant is associated with antidiabetes efficacy of | 第51-73页 |
| Abstract | 第52-53页 |
| 摘要 | 第53-54页 |
| 1 Introduction | 第54-55页 |
| 2 Materials and Method | 第55-64页 |
| ·Materials | 第55页 |
| ·Patient selection | 第55-56页 |
| ·Research method | 第56-64页 |
| 3 Results | 第64-67页 |
| ·There were no significant differences among the genotype at baseline | 第64-65页 |
| ·Comparison of fasting plasma glucose and life behavior before and after the treatment | 第65页 |
| ·polymorphism at rs 1057910 significantly affected therapeutic response to gliclazide in type 2 diabetes patients | 第65-67页 |
| 4 Discussion | 第67-69页 |
| 5 Conclusion | 第69-70页 |
| References | 第70-73页 |
| Review | 第73-92页 |
| 1 Biological characteristics of breast cancer stem cells | 第73-76页 |
| 2 Identification and culture of breast cancer stem cells | 第76-77页 |
| 3 Screening of breast micro spheres (mammosphere) model | 第77-78页 |
| 4 Signaling pathway of mediating breast cancer stem cells | 第78-79页 |
| 5 Current situation of breast cancer treatment | 第79-86页 |
| Review References | 第86-92页 |
| Publications | 第92-94页 |
| Patents | 第94-95页 |
| Acknowledgement | 第95页 |
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