| Abstract | 第5-6页 |
| 中文摘要 | 第8-10页 |
| Abbreviations | 第10-16页 |
| Chapter 1 Review: Circadian biology and metabolism | 第16-38页 |
| 1.1 Circadian biology | 第17-20页 |
| 1.2 Circadian clock network | 第20-24页 |
| 1.3 Functional diversity of PER gene family | 第24-26页 |
| 1.4 Circadian disruption and metabolic dysfunction | 第26-28页 |
| References | 第28-38页 |
| Chapter 2 Generation and characterization of hPER1~(S714G) mutant mice | 第38-56页 |
| Introduction | 第39-40页 |
| Materials and methods | 第40-44页 |
| Results | 第44-52页 |
| 2.1 Generation of transgenic mice carrying hPER1~(S714G) mutation | 第44-45页 |
| 2.2 Characterization of circadian phenotypes of hPERI~(S714G) mutant mice | 第45-52页 |
| Discussion | 第52-54页 |
| References | 第54-56页 |
| Chapter 3 hPER1~(S714G) mutant mice exhibit advanced feeding rhythm and metabolic misalignment | 第56-76页 |
| Introduction | 第57-58页 |
| Materials and methods | 第58-59页 |
| Results | 第59-73页 |
| 3.1 hPER1~(S714G) mutant mice exhibit advanced feeding rhythm | 第59-63页 |
| 3.2 hPER1~(S714G) mutant mice show a tendency to metabolic disorder | 第63-71页 |
| 3.3 Leptin may act as a mediator for advanced feeding rhythmin hPER1~(S714G) mutant mice | 第71-73页 |
| Discussion | 第73-74页 |
| References | 第74-76页 |
| Chapter 4 hPER1~(S714G) mutation accelerates circadian clock and reinforces internal misalignment | 第76-98页 |
| Introduction | 第77-78页 |
| Materials and methods | 第78-81页 |
| Results | 第81-94页 |
| 4.1 hPER1~(S714G) mutation decreases PER1 stability and fasten nuclei shuttling | 第81-88页 |
| 4.2 Altered feeding rhythms and clock defects reciprocally reinforce inernal misalignment | 第88-94页 |
| Discussion | 第94-96页 |
| References | 第96-98页 |
| Acknowledgements | 第98-99页 |
| Publicatioens | 第99-101页 |
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