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纳洛酮联合门冬氨酸鸟氨酸治疗肝硬化肝性脑病临床疗效观察
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【免费中医学论文】【摘要】 目的:探讨纳洛酮联合门冬氨酸鸟氨酸治疗肝性脑病的临床疗效。方法:将48例临床诊断的肝性脑病患者随机分成纳洛酮联合门冬氨酸鸟氨酸组(A组,n=24例)和纳洛酮组(B组,n=24例),A组给予纳洛酮0.4mg静脉推注,间隔4h 1次和门冬氨酸鸟氨酸10g静脉滴注,每日2次;B组给予纳洛酮0.4mg静脉推注,间隔4h 1次,疗程皆为7d。两组分别于治疗前、治疗7d后观察临床症状、血氨变化情况。结果:治疗7d后,A组治愈率、显效率和总有效率均明显高于B组(P<0.05),两组血氨较治疗前均明显下降(P<0.05),治疗后两组血氨及治疗前、后血氨浓度降低值差异均有统计学意义(P<0.05),两组均未见明显不良反应。结论:纳洛酮联合门冬氨酸鸟氨酸治疗肝性脑病比单用纳洛酮具有更好疗效,值得临床推广。 【关键词】 纳洛酮;门冬氨酸鸟氨酸;肝性脑病;肝硬化 [ABSTRACT] Objective: To investigate the clinical effects of naloxone combining with ornithine aspartate on hepatic encephalopathy induced by liver cirrhosis. Methods: Fortyeight patients with clinically confirmed hepatic encephalopathy were randomly divided into naloxone combining with ornithine aspartate group (group A, n=24), and naloxone group (group B, n=24).Group A was given naloxone 0.4 mg plus intravenous injection of 10 g ornithine aspartate by drips every 4 h
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