| | | 青岛市成人双生子吸烟饮酒遗传度分析
| | 医学实践论文【关键词】 成人双生子；遗传度；吸烟；饮酒
摘要： 目的医学实践论文 分析遗传因素对双生子吸烟、饮酒的医学实践论文影响。方法 以青岛地区自愿参加本研究的年龄≥24周岁的双生子为对象，在卵型鉴定的基础上，采用Holzinger方法分析其吸烟、饮酒的遗传度。结果 估计吸烟的遗传度为(665±553)％，重度吸烟的遗传度为(430±575)％。男性同卵双生子在吸烟行为上Kappa一致性检验K＝0453，P＜0001，异卵双生子K＝0307，P＝0005；饮酒的遗传度为(608±779)％，大量饮酒的遗传度为(222±980)％。男性同卵双生子在饮酒行为上Kappa一致性检验K＝0518，P＜0001，异卵双生子K＝0160，P＝0224。结论 吸烟、饮酒受遗传因素影响较大；重度吸烟、大量饮酒受遗传因素影响较小。男性同卵双生子在吸烟、饮酒行为上呈现中度一致性，男性异卵双生子、女性双生子一致性差异无统计学意义。
关键词： 成人双生子；遗传度；吸烟；饮酒
Analysis on heritability of cigarette smoking and alcohol drinking in adult twins in Qingdao city
Abstract： Objective To discuss the impact of inheritance on cigarette and alcohol consumption in twins.Methods Based on zygosity identification,the heritability of cigarette and alcohol consumption were studied in 503 pairs of twins,aged ≥ 24 years,who were voluntary to participate in this study.Holzinger analysis was employed to estimate the heritability of cigarette and alcohol consumption.Results The heritability estimated for cigarette smoking was (66.5±5.53)％,heavy smoking was (43.0±5.75)％,the Kappa consistency test was K＝0.453(P＜0.001) in Monozygotic(MZ),K＝0.307(P＝0.005) in Dizygotic(DZ);For alcohol consumption,the heritability was (60.8±7.79)％,amount of alcohol consumption was (22.2±9.80)％,the Kappa consistency was K＝0.518，P＜0.001 in MZ,K＝0.160，P＝0.224 in DZ.Conclusion The influence of heritability is larger on alcohol and cigarette consumption.A significant genetic effect could not be observed for the amount of alcohol and heavy smoking.Kappa Test is moderate consistency on cigarette and alcohol consumption in male monozygotic,but not on female twins and male dizygotic.
Key words： adult twins;heritability;cigarette smoking;alcohol consumption
吸烟、饮酒是导致的恶性肿瘤、心脑血管疾病等慢性非传染性疾病的因素之一。统计显示，恶性肿瘤、心脑血管疾病已成为青岛市死因顺位前2位。以往的研究发现，影响吸烟、饮酒的因素主要包括遗传基因、神经递质、个性特征、同龄人和家庭的影响、社会文化准则等，但这些研究多以描述性研究为主，未能综合地分析遗传因素和环境因素对吸烟、饮酒影响程度。本研究通过对青岛地区成人双生子吸烟、饮酒的问卷调查，估计成人吸烟、饮酒的遗传度。为预防和控制由吸烟、饮酒造成的慢性非传染性疾病提供科学依据。
1 对象与方法
11 对象 来自青岛地区双生子注册登记系统503对年龄≥24周岁的双生子，经过知情同意后参加本研究。
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