| | | 灯盏花素治疗老年不稳定心绞痛的疗效观察
| | 医学社会实践论文【摘要】 目的医学社会实践论文 观察灯盏花素对老年不稳定心绞痛的医学社会实践论文临床疗效和血液生化指标的影响。方法 给予不稳定心绞痛治疗组的86例患者用灯盏花素20ml静脉滴注14天，并设对照组60例。观察两组的临床疗效及对血液流变学的影响。结果 灯盏花素组临床总有效率为86.0%，对照组为66.7%,两组比较差异有显著性（P＜0.01）。灯盏花素组治疗后全血粘度、血浆粘度、红细胞比积及纤维蛋白原与治疗前比较均显著下降（P＜0.01或P＜0.05），其血液流变学改善程度明显优于对照组。结论 注射用灯盏花素是一种治疗不稳定心绞痛的有效药物，可抑制不稳定心绞痛的发作。
【关键词】 灯盏花素 ；老年人；不稳定心绞痛
【Abstract】 Objective To observe the influences of Breviscapine injection on the clinical therapeutic effect and hemorrheology in treating aged patients of unstable angina pectoris (UAP). Methods The cases with unstable angina pectoris were randomly divided into treatment group (86 cases) and control group (60cases). The treatment group were treated with 20ml of Breviscapine injection through intravenous drip for 14 days. The clinical therapeutic effect and the change of hemorrheologic characteristics were observed. Results The total effective rate was 86.0% in Breviscapine group and 66.7% in control group. The difference between the two groups was significant (P＜0.01). In Breviscapine group , the high and low shear whole blood viscosity,plasma viscosity, hematocrit and fibrinogen was lower after the treatment (P＜0.01 or P＜0.05).The improvement of hemorheology characteristics in Breviscapine group was more obvious than that in control group. Conclusion Breviscapine injection is a kind of effective drug in treating patients of UAP ,so it could inhibit the break out of UAP.
【Key words】 breviscapine;aged;unstable angina pectoris
不稳定心绞痛是介于急性心肌梗死和稳定性心绞痛的一组中间状态，早期干预可以防止其发展为心肌梗死或猝死。目前主要以抗缺血治疗为主。现代研究证明：灯盏花素具有改善冠状动脉循环，预防缺血、再灌注损伤和抗血小板凝聚的作用,是一种临床上有效的心肌保护药物［1］。近两年来，我院应用灯盏花素治疗老年不稳定心绞痛患者，取得满意效果，现报告如下。
1 资料与方法
1.1 一般资料 根据WHO及国际心脏病学会制定的《缺血性心脏病命名和诊断标准》，共诊断146例，其中男92例，女54例，年龄均≥60岁。按入院 时间随机分为治疗组86例，对照组60例。两组患者的年龄、性别、冠心病危险因素、入院时心绞痛症状及Killip心功能分级方面相仿，具有可比性。
1.2 治疗方法 所有入选病例均应用长效硝酸酯类、钙通道阻滞剂、β-受体阻滞剂、小剂量阿司匹林。治疗组加用5%葡萄糖溶液300ml+灯盏花素20ml，每日1次静脉滴注，14天为1个疗程。分别观察两组患者用药前后临床症状、十二导联心电图、血、尿常规、肝、肾功能、血脂、血液流变学的变化。
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