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肌浆网内钙容量减少对心肌细胞钙释放的影响
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【超声医学论文】 作者:沈建新,陈耀文,王海燕,韩太真【关键词】 钙释放Regulation of sarcoplasmic reticulum Ca2+ content depletion on cardiac Ca2+ release 【Abstract】 AIM: To systematically investigate the effects of sarcoplasmic reticulum (SR) Ca2+ content depletion on cardiac Ca2+ release. METHODS: Thapsigargin, a potent SR Ca2+ pump inhibitor, was used to deplete the SR Ca2+ content. The SR Ca2+ content was estimated by traditional caffeine puff. The global Ca2+ release was evoked by local field stimulation and the intracellular Ca2+ signal was recorded by the laser scanning confocal microscope. RESULTS: The results showed that thapsigargin decreased the SR Ca2+ content in a dosedependent and nonlinear timedependent manner. The intracellular Ca2+ release decreased with the depletion of SR Ca2+. But these two decreases were not parallel to each other. A slight depletion of SR Ca2+ could lead
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