|
|
|
氟美松对急性肝损伤大鼠肝细胞FasFas配体表达和细胞凋亡的影响
|
|
【免费西药学论文】 作者:周高速 张振书 王凡 林汉军 朱洁【关键词】 氟美松Effects of dexamethasone on Fas/Fas ligand expression and apoptosis of hepatocytes in rats with LPSinduced acute liver injury 【Abstract】 AIM: To investigate the changes of expression of hepatocytes apoptosis and Fas/Fas ligand (FasL) in lipopolysaccharide (LPS)induced acute liver injury in rats and the effects of treatment by dexamethasone and to evaluate the potential role and mechanism in the pathogenesis of acute liver injury. METHODS: Expression of Fas/FasL protein and mRNA was detected using immunohistochemistry and in situ hybridization, respectively. Apoptosis was determined by terminal UTP nick end labelling (TUNEL) in rats during every phase of acute liver injury. RESULTS: Expression of Fas/FasL protein and mRNA was upregulated and correlated with the increased apoptosis in hepatocytes of rats with lipopoly
|
|
|
|
<<<<<全文未完>>>>> 全文字数约2172字
|
要阅读全文请先注册成VIP会员!详情请阅读会员专区!
VIP会员可以阅读全文, 欢迎加入VIP会员专区! 加入VIP会员步骤如下:
注册用户名→在线购卡
|
|
|
|