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腺苷蛋氨酸对大鼠乙醇肝损伤的预防作用
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【西医学免费小论文】 作者:李涛,张永强,刘利兵,于军,陈健康,吴昊【关键词】 肝疾病Preventive effect of SadenosylLmethionine from alcoholic liver injury in rats 【Abstract】 AIM: To investigate the protective effects of SadenosylLmethionine (SAM) on alcoholic liver diseases. METHODS: Seventeen SD rats were randomly divided into 3 groups: alcohol control group, highdosage SAM group and lowdosage SAM group. Control group was only fed intragastrically with alcohol 6 mL/(kg・d) to establish the alcoholic liver injury model. The high and lowdosage SAM groups were injected with SAM at the dosage of 16 mg/(kg・d) and 32 mg/(kg・d) respectively before they were fed intragastrically with alcohol [6 mL/(kg・d)] to observe the preventative effect. All the rats were killed on the 26th day. γGT was examined and liver pathological sections were observed. RESULTS: The increasing trend of γGT i
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