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染料木黄酮与顺铂联用对耐药卵巢癌细胞SKOV
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【生物西药论文】 作者:袁鹏,黄艳红,辛晓燕,宋晖,田爽,王德堂【关键词】 染料bined with cisplatin on drugresistant ovarian carcinoma cell SKOV3 【Abstract】 AIM: To investigate the effects of genistein combined with cisplatin on the proliferation and apoptosis of drugresistant ovarian carcinoma cell SKOV3. METHODS: The growth inhibitory effect of genistein and cisplatin on SKOV3 cells was studied by MTT growth assay, the morphological alterations of SKOV3 cells were demonstrated by Hoechst 33342 staining under a fluorescence microscope and apoptosis and cell cycle distribution were detected by flow cytometry. RESULTS: Various concentrations of genistein in combination with cisplatin resulted in the reduction of IC50 by 32.3%-79.8% in SKOV3 cells. The combination index of genistein and cisplatin in SKOV3 cells ranged from 0.586 to 0.869, which indicated that they acted in a slightly to highly syner
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