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Paxillin在大鼠胰腺不同发育阶段的表达
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作者：郭静，滕丽萍，刘莉洁，程梅，蔺扬波，德伟
【关键词】 桩蛋白；胰岛形成；逆转录聚合酶链反应；基因芯片
Expression of paxillin during rat pancreatic development
【Abstract】AIM: To investigate the expression profile of genes related to islet formation and maturation during pancreas development. METHODS: The gene expression patterns in embryonic day 12.5(E12.5), E15.5, E18.5, newborn and adult pancreas were compared by using the GeneChip RAE 230A. The expressions of paxillin and actopaxin at different stages of rat pancreatic development were detected by RTPCR. RESULTS: Genes related to cell migration and adhesion (77.8%) were expressed at the highest level at E18.5, and the other ones (22.2%) peaked in newborn rats. The expression level of adult pancreas specific genes began to increase from E18.5, while some transcriptional factors expression began to decrease from E18.5. Paxillin and actopaxin were expressed at the highest level at E15.5. CONCLUSION: The later embryonic period may be important to pancreas development. Paxillin may play an important role in islet formation.
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