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补肾法对大鼠绝经后骨质疏松模型的影响
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作者：魏玉芳，王长海，刘钰林，张姗红，刘雅，李锋
【关键词】 补肾；骨质疏松,绝经后；骨密度；雌二醇
Therapeutic effect of invigorating kidney on postmenopausal osteoporosis in rats
【Abstract】 AIM: To study the therapeutic effect of invigorating the kidney on postmenopausal osteoporosis in rats. METHODS: Thirtytwo healthy female SD rats were randomly separated into 4 groups: normal group, model group, western medicine group, kidneyinvigorating group, 8 rats in each group. The postmenopausal osteoporosis model was established in the latter 3 groups by ovariectomy. One week later, rats in western medicine group were drenched with 50 mg/L nilestriol, 5 mL/week, and with 5 mL isotonic sodium chloride in other time; ones in kidneyinvigorating group were drenched with traditional Chinese medicine 200 g/L for tonifying the kidney, 5 mL/d, equivalent volume and concentration of sodium chloride was drenched every day in the same time to normal group and model group. Eight weeks later, blood from all the rats was harvested by removing eyeball, and left femoral bone was also taken. Bone mineral density (BMD) in femoral bone was measured by DPXPlus, and serum levels of E2 was detected by ELISA. RESULTS: In model group compared with other groups, BMD: normal vs model (P＜0.01); western medicine vs model (P＜0.01); kidney invigorating vs model (P＜0.01); E2: normal vs model (P＜0.01)； western medicine vs model (P＜0.01)； kidneyinvigorating vs model (P＜0.01); normal vs western medicine (P<0.01); normal vs kidneyinvigorating (P<0.01). CONCLUSION: Invigorating the kidney with traditional Chinese medicine can increase BMD, serum E2 in ovariectomized rat models, thus exerting the therapeutic effect on postmenopausal osteoporosis.
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