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痴呆患者血清和脑脊液中炎前和抗炎细胞因子的变化
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作者：李龙宣，赵斌，许志恩，邢孔鸯，唐荣华
【关键词】 痴呆；白介素1β；白介素6；肿瘤坏死因子α；白介素1受体拮抗剂
Changes of pro and antiinflammatory cytokines in serum and cerebrospinal fluid of patients with different kinds of dementias
【Abstract】 AIM: To observe the serum and cerebrospinal fluid (CSF) levels of the proinflammatory cytokines, interleukin1 β (IL1β), interleukin6 (IL6), tumor necrosis factor α (TNFα), and the antiinflammatory cytokine, interleukin1 receptor antagonist (IL1ra) in patients with different kinds of dementias and normal controls and to investigate their clinical meanings. METHODS: A total of 70 cases of patients with different kinds of dementias at the Department of Neurology in our hospital and Peoples Hospital of Taishan City from September 2003 to August 2005 were consecutively selected as the observed subjects, including 30 Alzheimers disease (AD) patients, 15 mixed dementia (MD) patients and 25 vascular dementia (VD) patients. The serum and CSF levels of IL1β, IL6, TNFα and IL1ra in the patients with different kinds of dementias and the controls were measured using ELISA. RESULTS: Compared to the controls, the levels of TNFα in CSF in the patients with different kinds of dementias were upregulated, whereas the level of IL1ra was downregulated to some extent (P<0.05 or P<0.01). The differences between the CSF levels of IL1β but not of IL6 in the patients with AD and those in the controls reached statistical significance (P<0.05). In contrast, the patients with VD displayed significantly higher CSF levels of IL6 but not of IL1β compared to the controls (P<0.05). The CSF levels of IL1β and IL6 in the patients with MD are both significantly higher than those in the controls (P<0.01). However, serum levels of IL1β, IL6, TNFα and IL1ra were not significantly different in the patients with different kinds of dementias in comparison with the controls. No correlations were found between CSF and serum levels of the cytokines. CONCLUSION: The changes of pro and antiinflammatory cytokines in the brain might be the factors of the neuropathological damage in AD, VD and MD.
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