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复方丹参滴丸人含药血清中丹参相关代谢产物的分析
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作者:郑晓晖,王世祥,赵新锋,赵欣,刘青,郑建斌 【关键词】 复方丹参滴丸;含药血清;色谱法,高压液相;代谢 Analysis on Danshenrelated metabolites induced by Compound Danshen Dripping Pills in human serum 【Abstract】 AIM: To detect Danshenrelated metabolites induced by Compound Danshen Dripping Pills in human serum and elucidate the possible metabolic pathway of those metabolites. METHODS: Column switchinghigh performance liquid chromatography was used to concentrate and separate the metabolites, which were detected by electrospray ionization trap mass spectrometry. The structure of the metabolites was analyzed by multistage mass spectrometry. RESULTS: Five new metabolites were found and their possible metabolic pathways were elucidated. CONCLUSION: This work has contributed to studying the intracorporal substantial foundation of Compound Danshen Dripping Pills.
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