| | | 花椒籽仁油对实验性高脂血症大鼠的防治作用
| | 临床医学检验论文 作者：刘永英，王多宁，刘渊声，杨颖，赵雁武，王增禄，杨继庆
【关键词】 花椒籽仁油；高脂血症；脂质代谢；血液黏度；氧自由基
Preventive and therapeutical effect of the kernel of zanthoxylum seed oil on experimental hyperlipidemia in rats
【Abstract】 AIM: To investigate the effect of the kernel of zanthoxylum seed oil （KZSO） on experimental hyperlipidemia in rats and to probe into the mechanism of preventive and therapeutical effect of KZSO. METHODS: Thirty healthy SD rats were randomly divided into 3 groups, including control group, hyperlipidemia model group and KZSO group. Control group was fed ordinary forage; model group was fed highlipid forage; KZSO group was administrated intragastrically KZSO besides highlipid forage. Blood samples were obtained by cutting necks after 10week feeding. The levels of blood lipids and the hemorheological parameters were determined, and the activities of superoxide dismutase (SOD) and catalase (CAT), the content of malondialdehyde (MDA) and the restraining ability to hydroxyl free radical (RAHFR) in the liver tissues were measured. RESULTS: Compared with the model group, cholesterol, triglyceride, high blood viscosity，and low blood viscosity of the KZSO group were decreased (P<0.05, P<0.01), highdensity lipoprotein cholesterol was increased (P<0.05). The activities of SOD and CAT and the RAHFR in the liver tissues of KZSO group were increased (P<0.05， P<0.01) and the content of MDA was decreased (P<0.05) as compared with the model group. CONCLUSION: KZSO can modulate the blood lipid, improve the indexes in hemorheology and prevent lipid hyperoxidation. The mechanism may be related to its componential effects.
【Keywords】 kernel of zanthoxylum seeds oil; hyperlipidemia; lipid metabolism; blood viscosity; oxygen free radical
【摘要】 目的临床医学检验论文： 研究花椒籽仁油对实验性高脂血症大鼠脂质代谢的临床医学检验论文影响，探讨其对高脂血症的防治作用机制. 方法：30只健康SD大鼠随机分为3组：对照组、高脂模型组及花椒油组，对照组普通饲料喂养，其余两组均高脂饲料喂养，花椒油组同时给予花椒籽仁油灌胃，10 wk后断颈取血，进行血脂、流变学检测，取肝组织测定SOD, CAT活性、MDA含量及抑制羟自由基能力. 结果：与模型组相比,花椒油组的CHOL，TG，HBV，LBV降低(P<0.05，P<0.01)，HDLC增高(P<0.05)，而肝组织匀浆的SOD，CAT活性及抑制羟自由基能力均增强(P<0.05，P<0.01)，MDA含量降低（P<0.05）. 结论：花椒籽仁油具有调节血脂、改善血流变、防止脂质过氧化的作用，其作用机制与其主要成分多不饱和脂肪酸的作用有关.
【关键词】 花椒籽仁油；高脂血症；脂质代谢；血液黏度；氧自由基
0引言
动脉粥样硬化（arteriosclerosis, AS）是临床上最常见的疾病之一，高脂血症是其重要致病因素，尤其是高胆固醇血症，与冠心病有着直接关系. 随着人们生活水平的提高、饮食结构的改变及人口老龄化的趋势，这些疾病的发病率越来越高. 因此，研究开发新型的功能性食品及药品，对防治冠心病具有十分重要的意义. 花椒籽仁油(kernel of zanthoxylum seeds oil， KZSO)是一类木本植物油，马传国等［1］对花椒籽皮油和仁油化学成分进行了分析，结果显示，花椒籽皮油中的酸值和过氧化值较高，容易劣变，而仁油则比较稳定，含不饱和脂肪酸高，主要是n3多不饱和脂肪酸(polyunsaturated fatty acid, PUFA). n3PUFA可以通过降低血脂来实现对心血管的保护作用［2-3］，花椒仁油对小鼠高脂血症有治疗作用［4］. 本实验我们进一步研究KZSO对实验性高脂血症大鼠脂质代谢的影响，探讨其对高脂血症的防治作用及机制.
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