|
|
|
抗血小板治疗对脑梗死患者血小板活化标记物表达的影响
|
| |
作者：周武，舒晓春，王雪晴，刘汉伟，韩蓉蓉，张苏明
【关键词】 血小板聚集抑制剂；脑梗死；CD62P；PAC
Influence of antiplatelet therapy on the expressions of platelet activation markers in patients with acute cerebral infarction
【Abstract】 AIM: To study the influence of different antiplatelet drugs on the expressions of platelet activation markers in patients with acute cerebral infarction aspirin and clopidogrel and provide reliable theoretical references for the prevention and therapy of acute cerebral infarction. METHODS: Flow cytometry was used to examine CD62P and PAC1, two platelet activation markers in patients with cerebral infarction. RESULTS: The expressions of platelet activation markers in patients with acute cerebral infarction patients was obviously higher than that in normal control group. The expression of platelet activation markers in acute cerebral infarction patients with diabetes and hypertension was much higher than that in acute cerebral infarction patients without diabetes and hypertension. Both aspirinand clopidogrel could inhibit the expression of platelet activation markers, but there was no remarkable difference between them. CONCLUSION: The activation of platelet plays a main role in the pathogenesis of acute cerebral infarction. Diabetes and Hypertension can aggravate the occurrence of acute cerebral infarction by enhancing the activation of platelet Both Aspirin and Clopidogrel could inhibit the expression of platelet activation markers and prevent relapse in acute cerebral infarction patients.
|
|
|
|
|
|
|
|
|
| 广告载入中... |
| 广告载入中... |
| 广告载入中... |
|
|
|
|
|
教育论文中心