| 2型糖尿病下肢血管病变患者中瘦素、白介素
| | 免费中药学论文 作者：谢晓敏，刘惠莉，于丽萍，李仁达，周海燕，张丽，曾斌，李玲，史静，牛旭东，侯庆宁，邹晓燕
【关键词】 糖尿病,2型；下肢；糖尿病血管病变；瘦素；白细胞介素
Alterations of serum leptin, interleukin6, Creactive protein during lower limb peripheral arterial disease in patients with type 2 diabetes
【Abstract】AIM: To investigate the association of leptin, interleukin6, Creactive protein with lower limb peripheral arterial disease (PAD) in patients with type 2 diabetes (T2DM). METHODS: A total of 125 T2DM patients were investigated with Bmode ultrasonography. Serum markers were measured .These clinical data and age,the duration of diabetes and ankle brachial index (ABI) were analyzed and compared among the patients with PAD (n=65), without PAD (n=60) and the controls (n=50). RESULTS: ① The duration of diabetes, Tc, ApoB were significantly increased in the patients with PAD compared with the ones without PAD and the normal controls （P<0.01, P<0.05）. The ABI were decreased in the patients with PAD compared with the ones without PAD （P<0.01）. ② In the patients with PAD, the serum levels of CRP, LEP were significantly higher than those of the ones without PAD (P<0.01). In the patients with PAD and without PAD, the serum levels of CRP, IL6 were significantly higher than those of the normal controls (P<0.01). CONCLUSION: The serum levels of CRP, IL6, LEP increased in T2DM patients with PAD. Serum levels of ABI, CRP, IL6, LEP should be measured earlier in T2DM patients who have long term duration and blood lipid disorders so as to prevent the occurrence of PAD.
【Keywords】 diabetes mellitus, type 2; lower extremity; diabetic angiopathies; Leptin; Interleukin6; Creactive protein
【摘要】 目的免费中药学论文： 研究2型糖尿病（T2DM）下肢血管病变与瘦素（LEP）,白细胞介素6（IL6）,C反应蛋白(CRP)的免费中药学论文关系. 方法： 对T2DM患者125例进行研究，其中病变组65例，糖尿病组60例，对照组50例，对下肢血管进行B超检测，并测定相应生化指标，结合年龄、病程、踝肱指数(ABI)等进行分析. 结果：① 病变组病程、血清总胆固醇、载脂蛋白B明显升高，与糖尿病(DM)组、对照组比较差异有统计学意义（P<0.01, P<0.05）；病变组ABI明显减低，与DM组比较差异有统计学意义（P<0.01）. ② 病变组LEP, CRP明显高于DM组（P<0.01）；病变组, DM组IL6, CRP显著高于对照组（P<0.01）. 结论： T2DM下肢血管病变患者存在素及炎症因子的增高. 对于T2DM病程长、血脂紊乱的患者应及早检测ABI, CRP, IL6, LEP水平，以便早期预防T2DM下肢血管病的发生发展.
【关键词】 糖尿病，2型；下肢；糖尿病血管病变；瘦素；白细胞介素6；C反应蛋白
0引言
2型糖尿病（T2DM）下肢血管病变是糖尿病（DM）重要的并发症之一，其发病率、致残率高，但未引起足够重视. DM下肢血管病变多发生于膝以下的胫、腓动脉，呈多部位节段性，病理改变为动脉硬化. 近年来炎症反应在DM发生、发展中的作用备受关注，越来越多的内分泌激素，如瘦素（LEP），炎症标志物，如白介素6（IL6）, C反应蛋白（CRP）等都与DM及其并发症相关联. 我们对T2DM下肢血管病变患者相关因子LEP, IL6, CRP进行检测，旨在研究LEP, IL6, CRP与T2DM合并下肢血管病变的关系.
1对象和方法
1.1对象选择我院住院的T2DM下肢血管病变患者65（男31，女34）例，为病变组，年龄36～75(平均60.79±9.75)岁，病程1～22 (8.22±5.83)a. 所有患者均有静息痛、下肢冷感、间歇性跛行、足背动脉减弱或足部溃疡等症状；做彩色多普勒超声检查确定所有患者下肢血管均有不同程度的病变，包括斑块、内膜增厚、血管硬化、血管狭窄等.选择同期住院做彩色多普勒超声检查确定无下肢血管病变的T2DM患者60（男29，女31）例，为DM组，年龄39~70(平均58.20±7.21)岁，病程1~20 (5.43±4.86)a，所有患者均无上述症状. 上述所有入选对象均符合WHO1999年制定的DM诊断标准. 对照组50（男24，女26）例为健康人，年龄34~70(平均58.54±8.38)岁. 三组间年龄、性别具有可比性.
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