| | | 饮食诱导肥胖和肥胖抵抗大鼠胃肠动力学研究
| | 动物医学毕业论文【关键词】 肥胖；肥胖抵抗；营养素吸收
摘要： 目的动物医学毕业论文 探讨高脂饮食诱导肥胖易感(OP)大鼠和肥胖抵抗(OR)大鼠胃肠动力和营养素吸收差异，从胃肠的动物医学毕业论文角度揭示肥胖和肥胖抵抗发生的原因。方法 高脂饲料喂饲健康雄性SD大鼠8周，筛选出OP大鼠和OR大鼠。实验结束后，连续进行3d代谢实验，并收集大鼠的粪便和尿液，分别测定其营养素含量，并计算出肥胖和肥胖抵抗大鼠的营养素消化吸收量。采用酚红灌胃法测定各组大鼠胃排空率，采用墨汁推进方法测定小肠推进功能。结果 OP大鼠蛋白质和脂肪的摄入量与吸收量显著高于OR大鼠。OP大鼠和OR大鼠胃排空率比较差异无统计学意义，OP大鼠小肠推进率显著高于OR大鼠。结论 在高脂饮食诱导下，胃肠动力差异以及营养素摄入和吸收的差异可能是导致肥胖和肥胖抵抗的原因之一。
关键词： 肥胖；肥胖抵抗；营养素吸收
Study on gastrointestinal function in obesity prone rats and obesity resistant rats induced by diet
Abstract： Objective To explore the differences of nutrients digested and absorptive as well as gastric empting,and intestinal transit in obesity prone (OP) rats and obesity resistant (OR) rats induced by highfat diet.Methods Male SpragueDawley(SD) rats were divided into OP rats and OR rats fed with high fat diet for 8 weeks.Then a threeday metabolism experiment was carried,and feces and urine were collected to measure the fat and protein.Phenol red administration was used to measure the rate of gastric empting and ink administration was used to measure the rate of intestinal transit.Results Obesity prone (OP) rats used more protein and fat than obesity resistant (OR) rats.The gastric empting rate had no significant difference in obesity prone (OP) rats and obesity resistant (OR) rats.The rate of intestinal transit in obesity prone (OP) rats was higher than that in obesity resistant (OR) rats.Conclusion With the high fat diet,one of the reasons that result in obesity prone (OP) rats and obesity resistant (OR) rats is the difference of nutrients digested and absorptive and gastrointestinal motor.
Key words： obesity;obesity resistance;nutrient absorption
众所周知，食物消化和吸收的主要器官是胃肠，它在进食、消化和营养物质吸收等方面起着十分重要的调控作用。而这些功能的有效发挥作用有赖于健全、协调的胃肠道动力的存在〔1〕。胃肠动力不仅调节营养素消化和吸收的速率，而且还参与食欲和饱腹感的调节〔2〕，并且通过神经系统来将各种信号传导到大脑的相应区域，这种传感方式很大程度上影响了摄食行为和总能量的平衡。有研究已经观察到肥胖病人胃肠动力的改变〔3〕，这些改变可能是肥胖发生发展过程中的作用因素之一。本文旨在从胃肠动力来探讨肥胖和肥胖抵抗机制。
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