| | | 运动对慢性心理应激大鼠影响
| | 药学论文范文
作者：张银娥，宋辉，杨惠芳，朱玲勤，旺岭，赵利华，田晓梅
【关键词】 慢性心理应激；运动；皮质醇；白细胞介素-2；白细胞介素-6
摘要： 目的药学论文范文 研究运动对慢性心理应激大鼠血清皮质醇、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)的药学论文范文影响。方法 建立慢性心理应激模型，进行6周游泳训练：测定各组大鼠血清皮质醇、IL-2、IL-6的含量。结果 (1)应激组大鼠血清皮质醇含量显著高于对照组(P<001)，血清IL-2、IL-6水平显著低于对照组(P<001);(2)30min运动组血清IL-2水平显著高于对照组(P<001)，60min运动组血清IL-2、IL-6水平均显著高于对照组(P<001)，血清皮质醇含量显著低于对照组(P<005);(3)应激+30min运动组、应激+60min运动组血清皮质醇含量显著低于应激组(P<001)，IL-2和IL-6水平显著高于应激组(P<001)。结论 慢性心理应激引起大鼠下丘脑-垂体-肾上腺皮质(HPA)轴释放过量皮质醇，使免疫功能受到抑制；适量运动能够调节HPA轴适应性，降低皮质醇的过量释放，维护免疫功能稳定。
关键词： 慢性心理应激；运动；皮质醇；白细胞介素-2；白细胞介素-6
Effects of physical exercise on chronic psychological stress in rats
Abstract： Objective To investigate the effect of exercise on the cortisol,interleukin-2 and interleukin-6 in rats of chronic psychological stress.Methods To construct chronic psychological stress model and carry out swim for 6 weeks in rats.The contents of cortisol,IL-2 and IL-6 were detected.Results (1)The plasma IL-2 and IL-6 levels in chronic psychological stress group was significantly lower than that in control group(P<0.01),while their cortisol level was significantly higher than that in control group(P<0.01).(2) The plasma IL-2 levels in 30min exercise group were significantly higher than that in control group(P<0.01);the plasma IL-2 and IL-6 levels in 60min exercise group were significantly higher than that in control group(P<0.01) while their cortisol level was significantly lower than that in control group(P<0.05);(3)The plasma IL-2 and IL-6 levels in both stress plus 30min exercise group and stress plus 60min exercise group were significantly higher than that in stress group(P<0.01),while their cortisol level was signficantly lower than that in stress group(P<0.01).Conclusion Chronic psychological stress depressed the immune function of rats,and exercise could effectively protect the immune system;Exercise could regulate the adaptation of hypothalamic-pituitary-adrenocortical(HPA) axle and the excretion of the hormone,which could be the possible mechanism that maintained the stability of the immune.
Key words： chronic psychological stress;exercise;cortisol;interleukin-2;interleukin-6
社会竞争导致职业人群职业紧张，即职业应激(occupational stress)。长期在应激状态下生活可导致机体抗病能力下降， 产生多种疾病，这可能是机体神经内分泌系统功能紊乱、免疫系统功能下降的一种反映。本文从提高机体免疫力来预防心理应激对机体造成的危害角度出发，通过制作慢性心理应激动物模型，以运动训练作为调节因素，检测大鼠血清皮质醇(cortisol)、白细胞介素-2(IL-2)及白细胞介素-6(IL-6)的含量，探讨运动训练对慢性心理应激神经内分泌及免疫功能的影响，为寻找职业应激的干预措施提供科学依据。
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