| | | 出生缺陷高发区地球化学环境中微量元素分析
| | 西医学 毕业论文下载【关键词】 ,高发区;发病率；元素含量；出生缺陷
摘要： 目的西医学 毕业论文下载 了解山西省出生缺陷高发区地球化学环境中微量元素含量与发病风险的西医学 毕业论文下载关系。方法 应用电感耦合等离子发射光谱仪(ICP)对山西省出生缺陷高发区中阳、交口县及低发区平遥县土壤、粮食、饮用水源和人发样品中As、Se、Mo、Zn、Sr、Fe、Sn、Mg、V、Cu、Al、K、S、Ca等14种元素含量进行测定，再用非参数检验和逐步回归等统计学方法对比分析出生缺陷高、低发区的样品中微量元素含量差异。结果 出生缺陷高发区环境中S元素含量高，Sr、Al元素含量低。此外，高发区与对照低发区的水、粮食以及人发中Mg、Mn、Mo、Fe、Cu、Ca和Sn的含量差异有统计学意义。结论 出生缺陷高发区和对照区土壤、粮食、饮用水源及人发中微量元素含量差异有统计学意义，可以通过环境因素中微量元素分析来推断出生缺陷发生风险高低。
关键词： 高发区;发病率；元素含量；出生缺陷
Analysis on trace element of geochemical environment in high prevalence area of birth defects
Abstract： Objective To explore the relationship between the content of trace elements of geochemical environment and the incidence of birth defects in the high prevalence area of birth defects.Methods The concentration of 14 kinds elements in the samples of soil,corn,water and hair from the high prevalence areas and the low one in Shanxi province were mensurated with Inductively Couplled Plasma(IGP) machine in the lab.Then the data were statistically analyzed and compared to find the difference of geochemical environment among these areas.Results Compared with the samples from the low prevalence area,the concentration of sulfur in the natural environment samples from high prevalence areas was significantly higher,but the concentration of strontium and aluminum were lower.Besides,and there were significant difference between the concentration of Mg,Mn,Mo,Fe,Cu,Ca and Sn in water and corn from the high prevalence birth defects area and that from the low one.Conclusion The concentration of trace elements in the samples of soil,corn,water and hair from the high birh defects ratio area and the low one has great difference,which can be used to deduce the occurrence of birth defects.
Key words：high prevalence area;incidence;concentration of elements;birth defects
出生缺陷发生与环境因素异常有关已被证实〔1〕，但已往的相关研究更多关注的是污染环境、生活环境及工作环境等次生环境的影响作用〔2-5〕。而大量研究表明，出生缺陷发生具有一定的地域集中性，存在明显的高发地区〔6,7〕。探讨出生缺陷高发区自然环境的异常特征，对出生缺陷的预防和干预很有意义。山西省是我国出生缺陷高发区，1996～2002年的调查数据表明，全省平均出生缺陷发生率为177%，农村地区高达277%〔8〕。本文采用对照比较法，探索出生缺陷发生率与地球化学环境异常特征之间的相关关系，为有效干预和防治出生缺陷的发生提供科学依据。
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