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p53基因突变和p16基因缺失与肝癌的相关性
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【关键词】 ,基因,p53；基因,p16；癌,肝细胞
Correlation of p53 gene mutation and p16 gene deletion with hepatocellular carcinoma
【Abstract】AIM: To detect the probability of p53 gene mutation and p16 gene deletion in the plasma of the patients with hepatocellular carcinoma (HCC) and to explore its correlation with onset and development of HCC and its clinical significance. METHODS: PCR was used to amplify p53 gene exon 58 and the immunohistochemistry (SPp16) was employed to determine the deletion of p16 gene. The difference between the patients with or without liver metastasis was analysed in gene mutation and deletion. RESULTS: Of 33 cases of HLL 17(51.55%), showed the mutation of p53; the mutation rate in metastasis group(n=18) was higher than that in nonmetastasis group(n=15). CONCLUSION: There is a correlation between HCC and p53 gene mutation and p16 gene deletion .The mutation rate may have the reference value in diagnosis and prognosis prediction of HCC.
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