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分泌型单链双功能抗体分子间接头的设计及软件分析
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【关键词】 抗体,双特异性；肿瘤坏死因子类；计算生物学
Design and analysis of linkers among secretary singlechain bifunctional antibody fusion molecules with bioinformatics software
【Abstract】 AIM: AIM: To analyze the secondary structure and the physical and chemical characteristics of the secretary antiosteosarcoma singlechain bifunctional antibody fusion protein with bioinformatics software. METHODS: The sites of enzyme were selected for the sequence of linker. Bioinformatics software was used to analyze structural change of the singlechain antibody fragments of variable domaintumor necrosis factor (ScFvTNF) fusion protein, and then DNAssist and ANTHEPROT V5 were used to analyze its sequence, secondary structure, and physical and chemical characteristics. RESULTS: On the fusion genes, the sites of enzyme were selected for the sequence of linker, and the secondary structure of the fusion protein was obtained with DNAssist, and the physical and chemical characteristics of the fusion protein were forecasted with ANTHEPROT V5. CONCLUSION: The software for bioinformatics should be fully utilized to analyze biological information, and be improved continuously. Bioinformatics can shorten the course of pharmaceutical development, at the same time can help us to explore the genebased medicine.
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