| | | 椎体模型内模拟注射PMMA的流动及分布规律
| | 中药师论文【关键词】 椎体成形术；聚甲基异丁烯酸；多孔介质；椎体模型
Law of PMMA flowing and distributing in the vertebra by computer modeling
【Abstract】AIM: To investigate the law that PMMA (polymethylmethacrylate) flows and distributes in the vertebra so as to lay the operational theoretical foundation for the clinical work of percutaneous vertebroplasty. METHODS: Based on the structural characteristics and parameters of the healthy adult vertebra,a vertebral model of porous media was made by the computer software and the law that silicone oil with a viscosity matching that of PMMA flew and distributed in the model was calculated and analyzed by means of hydrodynamics and numeric modeling. RESULTS: The silicone oil distributed in a circlelike shape on each plane in the vertebral model,and the largest amount was on the planes through the injection point.The volume fraction of the silicone oil decreased from the center of planes to outward on each plane. CONCLUSION: The law that PMMA flows and distributes in the vertebral model was to spread in all directions in a circlelike shape on the planes through the injection point as a centre and it finally became a balllike shape as a whole.
【Keywords】 vertebroplasty; polymethyl methacrylate; porous media;vertebral model
【摘要】目的中药师论文： 探寻骨水泥在椎体内的中药师论文流动及分布规律，为临床椎体成形术提供操作的理论基础. 方法： 根据正常成人椎体的结构特性和参数运用计算机软件构建相应的多孔介质的椎体模型，并运用流体力学的方法进行数值模拟和分析与骨水泥粘度相当的硅油在椎体模型中的流动及分布规律. 结果： 硅油在模拟的椎体模型内的各个平面上呈类圆形分布，位于通过注射点的平面面积最大,在每个平面上从中心向外,硅油的体积分数逐渐降低. 结论：模拟骨水泥在椎体内的流动分布规律：以注射点为圆心，在经过注射点的各个平面上，向各个方向呈类圆形流动分布，成为一个类球体的结构.
【关键词】椎体成形术；聚甲基异丁烯酸；多孔介质；椎体模型
0引言
经皮椎体成形术是目前治疗椎体病变(如高危骨质疏松椎体、骨质疏松导致的椎体骨折,椎体肿瘤等)较为常用、有效的方法之一. 尽管经皮椎体成形术有常规严格的手术操作程序，但临床尚有诸多并发症发生，其中较为严重且常见的并发症为骨水泥的渗漏，对骨水泥注入过程中其流动分布规律的认识不清楚是导致该并发症发生的关键因素之一. 模拟研究骨水泥在正常椎体模型内的流动分布规律，为椎体成形术的操作提供基础理论依据，为临床相关治疗提供指导.
1材料和方法
1.1材料试验用椎体来源于解剖室２具青年男尸（年龄２３岁和３２岁）的胸腰段椎体共３个，所有标本经x线前后方向和侧向检查排除椎体的病变. 经过950 mL/L乙醇脱脂后，标明标记后存于-20℃冰柜中待用. 试验选用与骨水泥粘度相当的标准10万粘度的硅油（美国道康宁公司）作为模拟注射用的流体.
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