| | | 射频消融治疗悬雍垂腭咽成形术后无效的阻塞性睡眠呼吸暂停低通气综合征
| | 西医学 论文下载[摘要] 目的西医学 论文下载 探讨等离子低温射频消融(temperature-controlled radiofrequency ablation,RFA)治疗悬雍垂腭咽成形术(uvulopalatopharyngoplasty,UPPP)术后无效的西医学 论文下载阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的疗效。方法 选择19例UPPP术后无效的OSAHS患者接受RFA治疗。比较治疗前后呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO2)、鼾声评级和Epworth嗜睡程度评分,评价治疗效果。结果 治疗总有效率68.4%,患者治疗8周后鼾声评级的降低较治疗前差异无显著性,Epworth嗜睡程度评分较治疗前降低非常明显(P<0.01)。治疗后6个月AHI较治疗前减低明显(P<0.05),LSaO2较治疗前升高明显(P<0.05)。结论 对UPPP术后无效的OSAHS,RFA是一种有效的治疗方法。 [关键词] 射频消融;阻塞性睡眠呼吸暂停低通气综合征 Curative effect of radiofrequency ablation on ineffective obstructive sleep apnea hypopnea syndrome after uvulopalatopharyngoplasty [Abstract] Objective To investigate the curative effect of radiofrequency ablation(RFA )on ineffective obstructive sleep apnea hypopnea syndrome(OSAHS) after uvulopalatopharyngoplasty(UPPP).Methods 19 cases of OSAHS which were ineffective after UPPP were chosen to accept RFA.Preoperative apnea hypopnea index(AHI),lowest saturation of blood oxygen(LSaO2),snoring scale and Epworth sleepiness scale were compared with those postoperative to value the curative effect of RFA.Results The effective ratio was 68.4%.8 weeks after treatment,Epworth sleepiness scale decreased much significantly(P<0.01),there was no difference on snoring scale.6 months after operation,lowest saturation of blood oxygen(LSaO2) improved significantly(P<0.05),in addition,apnea hypopnea index(AHI) decreased significantly(P<0.05).Conclusion RFA is an effective treatment to ineffective OSAHS after UPPP. [Key words] radiofrequency ablation;obstructive sleep apnea hypopnea syndrome 悬雍垂腭咽成形术(uvulopalatopharyngoplasty,UPPP)是治疗阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的最有效方法之一,但由于OSAHS的发病因素复杂,与年龄、肥胖、上呼吸道形态异常及内分泌改变等多种因素有关,患者上气道阻塞部位不同,解剖特点不同,个体差异较大,易造成UPPP术后疗效不佳,国内外报道远期疗效一般在50%左右。本研究探讨等离子低温射频消融(temperature-controlled radiofrequency ablation,RFA)治疗UPPP术后无效的OSAHS的疗效。 1 资料与方法 1.1 一般资料 选择19例UPPP术后无效的OSAHS患者接受RFA治疗,男17例,女2例,年龄(50.6±6.9)岁。所有患者均经Compumedics型多导睡眠仪(Compumedics Ltd,Australia)行多导睡眠图(polysomnography,PSG)监测确诊,根据杭州会议的诊断标准[1],呼吸暂停低通气指数(apnea hypopnea index,AHI)5~20为轻度2例,21~40为中度13例,>40为重度4例。最低血氧饱和度(LSaO2)≥85%为轻度低氧血症3例,65%~84%为中度15例,<65%为重度1例。阻塞平面位于腭咽和(或)舌咽水平,除外慢性支气管炎、肺气肿、脑血栓、冠心病和心力衰竭等心脑血管器质性疾病。患者一般情况见表1。
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