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溶血性、非溶血性肠球菌的毒力差异
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【西医药学毕业论文】【关键词】 肠球菌属;,溶血素类;,毒力;,药物耐受性摘要:目的 探讨肠球菌溶血素与毒力的关系。 方法 比较溶血性肠球菌在临床标本及健康人群粪便标本的检出率;比较溶血性、非溶血性肠球菌对小鼠的LD50及其对9种抗生素的敏感性。结果 临床标本肠球菌的溶血素检出率61.5%,高于健康人群粪便标本(18.4%,P<0.05);溶血性肠球菌的LD50[(3.9~11)×108cfu/mL]比非溶血性肠球菌小[(2.5~8.9)×1010cfu/mL,P<0.01]。除丁胺卡那、万古霉素外，溶血性肠球菌对抗生素的耐药性明显高于非溶血株。结论 肠球菌的溶血素可能与其毒力有关。
关键词:肠球菌属; 溶血素类; 毒力; 药物耐受性
Difference of Enterococci Virulence between Hemolytic and Non Hemolytic Strains
Qiang Hua, Xie Manling
Division of Etiology, Fujian Medical University, Fuzhou 350004, China
ABSTRACT: Objective To investigate the relation between enterococcus hemolysin and its virulence. Methods Incidence of hemolysin of enterococci derived from clinical isolates and healthy people fecal specimens were examined respectively; LD50 and antibiotic susceptibilities were compared between hemolytic strains and non hemolytic strains. Results Strains derived from
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