|
|
|
冰片-薄荷脑二元低共熔混合物对盐酸川芎嗪经皮渗透的影响
|
|
【免费西医学论文】【摘要】 [目的] 研究 冰片-薄荷脑二元低共熔混合物对盐酸川芎嗪透皮经皮渗透的 影响 ,考察其作为药物经皮渗透促进剂的可行性。[ 方法 ]采用Franz扩散池,以离体大鼠皮肤为透皮屏障,以紫外分光光度法测定药物含量求算累积渗透量。[结果]8%冰片-薄荷脑低共熔混合物对盐酸川芎嗪的体外经皮渗透具有较好促进作用,与对照组和氮酮组相比,渗透速率分别提高了5.8倍和4.7倍。[结论]该低共熔混合物对盐酸川芎嗪经皮渗透具有明显促进作用,是一种较好的新型促进剂,具有良好的开发 应用 前景。 【关键词】 冰片-薄荷脑二元低共熔混合物;盐酸川芎嗪;经皮给药;渗透促进剂 Abstract:[Objective]To study the effects of BorneolMenthol binary eutectic mixture on transdermal permeation of tetramethylpyrazine hydrochloride(TMPH)and to investigate the feasibility of traditional chinese medicine (i.e.eutectic mixture) as permeation enhancers of tetramethylpyrazine hydrochloride(TMPH).[Method]Transdermal flux of TMPH through rat skin was determined in vitro by Franztype diffusion cells. The concentrations of TMPH in receptor compartment at specified time points were determined by UV.[Result]The transdermal fluxs of the TMPH using eutectic mixture as enhancers was 5.
|
|
|
|
<<<<<全文未完>>>>> 全文字数约3631字
|
要阅读全文请先注册成VIP会员!详情请阅读会员专区!
VIP会员可以阅读全文, 欢迎加入VIP会员专区! 加入VIP会员步骤如下:
注册用户名→在线购卡
|
|
|
|