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硫必利凝胶的皮肤渗透性实验研究
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【西医学免费论文下载】作者:花永刚 姜一飞 卜媛媛 刘丽霞【摘要】 目的 研究 硫必利凝胶的皮肤渗透性。 方法 制备含不同浓度的氮酮、薄荷脑等促透剂的硫必利凝胶,采用改进的Franz扩散池,用离体小鼠皮进行体外作用研究。紫外分光光度法测定硫必利累积渗透量及渗透速率。结果4%丙二醇和氮酮或4%丙二醇和薄荷脑配合对2.5%硫必利凝胶的促透效果较好。在含5%以上硫必利凝胶时,单用氮酮或薄荷脑为佳。结论4%的氮酮或薄荷脑对10%硫必利凝胶的促透效果最好。 【关键词】 硫必利凝胶 氮酮 薄荷脑 渗透性 Experimental stady of percutaneous permeability of taipride gel 【Abstract】ObjectiveTo study the percutaneous permeability of tiapride gel;MethodsTiapide gel contaning different concentrations of menthol and azone was preparated. The steady state flux of tiapride from gel was determined in vitro on excised mouse skin utilizing modified Franz diffusion cells.The accumulation permeation amounts and permeation rate were calutated. ResultsThe results of permeability is more effective when to use the complex of 4% propylene glycol and azone or 4% propylene glycol and menthol to 2.5% tiapride gel. And it is better to use azone
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