|
益气补肺方对急性肺损伤大鼠ET-1和MIF水平的影响
|
|
【医学教育论文下载】作者:杨勇 傅晓青 董礼文 王军 程根苗【摘要】 目的 探讨益气补肺方对油酸性急性肺损伤大鼠的ET-1和MIF水平及肺组织学的 影响 及保护机制。 方法 将动物随机分为五组:中药组、西药组、中+西药组、模型组、正常组。用油酸诱发急性肺损伤,观察造模后大鼠肺系数、肺组织匀浆ET-1和MIF水平、肺组织学改变。 结果 与油酸组比较,中药组与中+西药组ET-1和MIF水平明显降低(P<0.05),其中3组用药组间ET-1水平差异具有显著性(P<0.05)。 结论 益气补肺方对油酸诱发的大鼠急性肺损伤有一定的保护作用,抑制ET-1和MIF生成是其作用机制之一。 【关键词】 益气补肺方 急性肺损伤 ET-1 MIF 肺组织学 【Abstract】 Objective To study effects and mechanism of "Yi Qi Bu Fei Formula(YBF)" on ET-1 and MIF levels and lung histology in acute rats lung injury(ALI) induced by oleic acid . Methods The rats were randomly divided into five groups: YBF,dexamethasone(DXM), YBF+DXM, positive control, negative control. The model was set up by intravenous injection of oleic acid. The lung ratio, ET-1 and MIF levels in lung tissue, lung histologic examinations were conducted after oleic acid injection. Results Compared to those in positive control group, ET-1 and MIF
|
|
|