|
|
|
含二茂铁的二氢吡啶衍生物的合成方法
|
|
【免费西医学论文】【摘要】 目的 利用常规加热法向二氢吡啶环上引入二茂铁基团,探索最佳反应条件。 方法 分析 不同氮源(包括碳酸氢铵、尿素、醋酸铵)、不同时间及溶剂对该类反应的 影响 。 结果 醋酸铵为氮源,57 ℃左右,无溶剂反应90 min,顺利制得目标物,产率79.3%。 结论 常规加热条件下无溶剂一步合成含二茂铁的二氢吡啶衍生物,该方法不仅产率提高,避免产生副产物,而且污染小,符合绿色化学的要求,更适用于 工业 生产。 【关键词】 亚铁化合物; 二氢吡啶类; 方法 ABSTRACT: Objective To introduce ferrocenyl group into the dihydropyridine ring by using conventional heating under optimized reaction conditions. Methods To evaluate the influences of reaction conditions such as different nitrogen resources including ammonium bicarbonate, urea and ammonium acetate, different reaction times and reaction solvents. Results The target was obtained with the yield of 79.3% by using ammonium acetate as nitrogen source under around 57 ℃ for 90 min in the absence of solvent. Conclusion Conventional heating was used in a solvent free one-pot reaction to synthesize ferrocenyl-dihydropyridine derivatives. Compare
|
|
|
|
<<<<<全文未完>>>>> 全文字数约1851字
|
要阅读全文请先注册成VIP会员!详情请阅读会员专区!
VIP会员可以阅读全文, 欢迎加入VIP会员专区! 加入VIP会员步骤如下:
注册用户名→在线购卡
|
|
|
|