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Locally Advanced Pancreatic Cancer: Current Therapeutic Approach
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【西医学实践论文】作者：Higinia R. Cardenesa, Elena G. Chioreanb, John DeWittc, Max Schmidtd, Patrick Loehrerb
【关键词】 Pancreatic,cancer
Key Words. Pancreatic cancer ; Locally advanced disease ; Chemoradiotherapy ; Surgery ; Molecular targeted therapy
ABSTRACT
Even though pancreatic cancer accounts for only 2% of all cancer diagnoses in the U.S., it is the fourth-leading cause of cancer death and one of the most difficult malignancies to manage. Because of the usually late onset of symptoms, only 10%15% of patients present with resectable disease, whereas the remaining 85%90% present with locally advanced unresectable or metastatic disease. Despite a lack of consistent evidence from previous clinical trials, chemotherapy in addition to radiation therapy is the most commonly used approach in treating locally advanced pancreatic cancer. The most appropriate chemotherapy in combi
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