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蒿甲醚对BALB/c小鼠CT-26结直肠癌抑瘤作用
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【药学毕业论文怎么写】作者:伍治平 高成伟 王熙才 吴永贵 朱启顺 胡炜【摘要】 [目的] 探讨蒿甲醚(Artemether)对BALB/c小鼠CT-26 结直肠癌的抑瘤作用。[ 方法 ] BALB/c小鼠皮下接种CT-26 结直肠癌细胞(2×106)48只,雌雄各半;随机分为6组,每组8只,分别为低剂量(33.3mg/kg)、中剂量(50mg/kg)、高剂量(66.6mg/kg)和中剂量(50mg/kg)+铁剂(1.5mg/kg)组,阳性对照组为顺铂(5mg/kg),空白对照组为等体积生理盐水。除顺铂为腹腔注射外,其余组均为灌胃给药法。[结果] 口服蒿甲醚低、中、高剂量和中剂量+铁剂对BALB/c小鼠CT-26结直肠癌的抑瘤率分别为:42.3%、51.4%、52.0%、53.5%。[结论] 在一定剂量范围内,口服蒿甲醚对小鼠CT-26结直肠癌有明显的抑制作用;蒿甲醚与铁剂合用具有一定的协同作用。 Anti-tumor Effect of Artemether in CT-26 Colorectal Cancer Bearing BALB/c Mice Abstract: [Purpose] To explore the anti-tumor effect of Artemether in CT-26 colorectal cancer bearing BALB/c mice. [Methods] Forty-eight BALB/c mice (24 male and 24 female) subcutaneous planted with CT-26 colorectal cancer cell (2×106) were randomly divided into 6 groups(8 mice in each): low dose group, 33.3mg/kg; middle dose group,50mg/kg; high dose group, 66.6mg/kg; Artemether 50mg/kg plus ferralia 1
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