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SNP芯片技术进展
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【西药学论文范文】作者：董园园，盛海辉， 陈光，张春秀【摘要】 SNP具有数量多、分布广、易于快速检测、便于分型等特点，其分析检测技术的发展也引起了众多研究人员的重视，不断有新的检测方法出现。RFLP技术、SBE技术、TaqMan技术、L-RCA技术等为SNP的检测提供了快捷准确的方法。由于SNP之间的关联紧密复杂，因此需要一种有效的检测方法，芯片检测作为一种低成本、高通量的检测方法已成为大规模SNP分析的有力检测工具，将来可为遗传学研究分析、个体化医疗的实施提供强有力的技术保障。
【关键词】 单核苷酸多态性；芯片；分型；个体化医疗
【Abstract】 SNP is widely distributed in the human genome and it attracts the interest of many scientists. It can be detected much easier and faster. Several detection methods have been developed with high sensitivity in last years such as RFLP technology, single base extension method, TaqMan technology and L-RCA technology. Because of complicated relationship between SNP, it needs an effective detection. As an inexpensive and high throughput approach, microarray can give a guidance for personalized medicine in clinical and apply a diagnosis instrument for personalized treatment in the future.
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